The Aseptic Liquid Filling Machine is a designed equipment made to fill liquid products in a manner that they remain germ-free and without any contamination. This machine is widely used in the pharmaceutical, biotechnology, and healthcare industries for filling injectable products, vaccines, ophthalmic solutions, and other sterile liquids that require complete sterility and precision.
Aseptic Liquid Filling Machine Video
Sterile Construction for Critical Environments
Fabricated from SS 316L contact parts, the entire Aseptic Liquid Filling Machine is made of stainless steel construction, built following GMP and FDA standards. The seamless design provides a reduced contamination risk and is compatible with cleanroom integration and easy sterilization, allowing compliance with aseptic manufacturing protocols.
How It Works?
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Container Infeed:
Sterile containers, such as vials or bottles, are automatically fed into the machine via a conveyor system, spaced precisely by an infeed star wheel or stopper mechanism for accurate alignment. -
Aseptic Liquid Filling:
The liquid filling process uses a high-precision volumetric filling system (typically piston or peristaltic pump-based) operated under laminar airflow or within an isolator/RABS (optional) environment. Each dose is filled with exceptional accuracy under sterile conditions. -
Stoppering (Optional):
If required, rubber stoppers or sealing components are placed immediately after filling using a vacuum-assisted pick-and-place system, maintaining sterility throughout. - Exit & Transfer:
Filled and sealed containers are transferred smoothly to the next phase of the sterile packaging line, such as capping or crimping stations.
Key Features of Aseptic Liquid Filling Machine
- Aseptic Grade Design
Cleanroom-compatible construction with low dead zones and cleanable surfaces.
- GMP Compliant Construction
Hygienic design of mechanical components using SS 304/316L.
- No Vial – No Fill System
The machine automatically stops filling when it does not detect any container, preventing wastage and the product.
- No Stopper – Machine Stop System
Prevents product loss by immediately stopping the machine.
- High Fill Accuracy
Provides a very small deviation from the fill volume due to its pump mechanism- volumetric or peristaltic.
- Minimal Product Contact Time
Constraints exposure to the product and maintains sterile conditions.
- Tool-Free Maintenance
Disassembly of components is quick and simple for autoclaving and cleaning; no special tools are required.
- Compact Footprint
High-throughput performance in a space-saving design for a cleanroom.
Technical Highlights
Common Features Across All Models:
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Vial Diameter Range: 15mm to 70mm
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Vial Height Range: 25mm to 140mm
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Filling Precision: ±1%
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Electrical Requirement: 440 Volts, 3 Phase, 50 Hertz
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Power voltage can be adjusted as per the client’s requirement
All models were constructed with GMP-compliant SS materials
Technical Specification of Aseptic Liquid Filling Machine
| Model | ALVF-40 | ALVF-80 | ALVF-120 | ALVF-250 |
| Number of Filling Heads | Two | Four | Eight | Twelve |
| Production Rate | Up to 40 vials/minute | Up to 80 vials/ minute | Up to 150 vials/minute | Up to 250 vials/minute |
| Power Required | 1 H.P. | 1.5 H.P. | 2 H.P. | 2 H.P. |
| Overall Dimensions | 2050mm (L) x 850mm (W) x 1700mm (H) approx. | 2200mm (L) x 850mm (W) x 1700mm (H) approx. | 3000mm (L) x 945mm (W) x 1700mm (H) approx. | 3500mm (L) x 945mm (W) x 1700mm (H) approx. |
* Power voltage can be adjusted as per customer’s domestic power voltage requirements.
* Rights of technical improvements & modification reserved.
* Illustrations & dimensions are shown for information purpose only.
*Custom models are available with Isolator/RABS and SCADA integration upon request.
The Aseptic Liquid Filling Machine is a combination of sterility, accuracy, and GMP compliance design for pharmaceutical and biotech companies. As a state-of-the-art asset in sterile production lines, it ensures product quality, safety, and compliance. It is differentiated by its innovative design, top-of-the-line manufacturing, and low downtime.
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