Tablet Production Line

Tablet Production Line (Tablet processing line) including tablet manufacturing line consist of Sieving, Blending, Milling, Drying, Granules Forming, Lubrication, Tablet Compression and Tablet Blister Packaging Machines. We offer tablet compression lines for wet granulation as well as dry granulation. All machines complies as cGMP standard manufacturing requirements. Adinath range offers Small Production Tablet Line as well as High-Speed Tablet Production Line.

Tablet Production Process

Tablets are formed by compression of powdered, crystalline, or granular active materials (API), alone or in combination with certain exponents as required, such as binders disintegrants, sustained release polymers, lubricants, diluents, flavors and colorants. Tablet manufacturing process can be widely divided into three major steps which are wet granulation, dry granulation and direct compression. Type of product to be manufacture decides that which process you should follow. We are giving here below detail information about all three-tablet production process:

Wet Granulation

This is the most widely used method of tablet preparation. In this method the powders are bound by suitable binder by “adhesion”. The binder is added by diluting with suitable solvent prior to addition to the blended powders to form wet granules which in turn are dried suitably to expel the solvent forming dried granules. The surface tension forces, and capillary pressure are primarily responsible for initial granules formation. The main advantage being it meets all the requirements for tablet formation though it is multistage, time consuming.

Dry Granulation

Dry granulation process is uses to form granules without using a liquid solution. This type of process is recommended for products, which are sensitive to moister and heat. Forming granules without moisture requires compacting and densifying the powders. Dry granulation can be done on a tablet press using slugging tooling. On large-scale roller compactor commonly referred to as a powder compacting. The compacted mass is called slugs, and the process is known as slugging. The slugs are then screened or milled to produce a granular form of tablet materials, which have the good flow properties then original powder mixture. The main advantage of dry granulation is it requires less equipment and eliminates the addition of moisture and the application of heat, as found in wet massing and drying steps of the wet granulation method. The manufacture of oral solid dosage forms such as tablets is complex multi-stage process under which the starting materials change their physical characteristics a number of times before the final dosage form is produced. Traditionally, tablets have been made by granulation, a process that imparts two primary requisites to formulate: compactibility and fluidity. Both wet granulation and dry granulation (slugging and roll compaction) are used. Regardless of weather tablets are made by direct compression or granulation, the first step, milling and mixing, is the same; subsequent step differ. Numerous unit processes are involved in making tablets, including particle size reduction and sizing, blending, granulation, drying, compaction, and (frequently) coating. Various factors associated with these processes can seriously affect content uniformity,bioavailability, or stability.

Direct Compression

The tablets are made by directly compressing the powdered materials without modifying the physical nature of the materials itself. Direct compression is generally done for the crystalline materials having good physical properties such as flow property, compressibility. Main advantages of direct compression is time saving, safety of operations and low cost.

Tablet Production Line generally consist below mentioned functions and equipment’s. We are giving here below step-by-step tablet processing flow chart with machine details:

• STEP 1 – Powder- Raw Material
• STEP 2 – Grading & sieving Process (Machine – Vibro Sifter)
• STEP 3 – Dry & Wet mixing with binder (Machine –High Shear Mixer OR Mass Mixer)
  Starch Paste Preparation (Machine-Paste Making Kettle)
• STEP 4 – Lumps Milling (Machine Multi mill / Cone Mill/Comminuting Mill / Oscillating Granulator)
• STEP 5 – Wet Material Drying (Machine – Fluid Bed Drier OR Tray Dryer Oven)
• STEP 6 – Forming Granules (M/c Multi mill / Cone Mill/Comminuting Mill / Oscillating Granulator)
• STEP 7 – Grading & sieving (Machine – Vibro Sifter)
• STEP 8 – Lubrication of granules for free flowing (M/c Blender Octagonal / Double & V Cone, Bin)
• STEP 9 – Tablet Compression (Machine – Tablet Press & Die & Punch
• STEP 10 – Tablet De Dusting (Machine – Vibro De Duster)
• STEP 11 – Powder dust extracting during tablet compression (Dust Extractor Unit)
• STEP 12 – Film & Sugar Coating of tablets (Machine – Auto Coater or Conventional coating)
  Coating solution preparation (Machine – Stirrer & Colloid Mill)
• STEP 13 – After That Tablets will be inspected and Packed.

Vibro Sifter

Vibro Sifter (vibrating sieve) unit consisting of circular pre-tensioned screen mounted on the frame along with vibrating motor. The vibrating motor imparts three plane vibrations to the screen due to revolving eccentric weights. Total assembly is mounted on suitable springs so that it becomes a independent body which vibrates without parting any vibrations to the foundations.

Rapid Mixer Granulator

Rapid Mixer Granulator is designed to achieve in reducing processing time, more homogenous mixing consistent granules at lower operating cost and above all maintaining improved hygienic compliant to cGMP norm. Rapid Mixer Granulator working principles are based on two decisive factors essential for the intimate mixing system. 1. Spinning close to bottom of mixing bowl and 2. The impeller sets the entire mixture in whirling rising.

Multi Mill

Multi Mill is a self-contained portable unit useful for high-speed granulating, pulverizing, mixing, shredding and chopping of wide range of wet and dry materials without special attachments. As compared to the four common principles of size reduction i.e., grinding, compression, impact and shearing, which often do not produce controlled size reduction, this machine utilizes the principle of variable force swing hammer blades having both knife and impact edges rotating with a carefully selected screen to control size reduction. Flow path of material in vertical rotor machine is streamlined. During comminution, material entering the chamber travels to the periphery and passes through the screen tangentially and radially, avoiding chocking and temperature rise.

Fluid Bed Dryer

Fluid Bed Dryers are designed to Uniform drying of the material at low temperature. Fluid Bed Dryers are made of Stainless Steel 304/316 with GMP standards. The complete unit is supplied with Suitable motor, blower, filters, filter bag, control panel. Heating system provided as per specific customer requirements.

Octagonal Blender

Octagonal Blender (octagonal mixer) including octagonal shape machine is suitable for the mixing granular products. The machine offers great flexibility of operations as well as easy cleaning and maintenance. Simple structure with GMP-compliant design further enhances the functionality of the machine. The Octagonal Blender is an efficient and versatile blending machine for mixing and lubrication process of dry granules homogeneously. Two third of the volume of the Cone Blender is filled to ensure proper mixing.

Tablet Compression Machine

Our range of Tablet Compression Machine includes single and double rotary tablet press machine with hygienic features. Our Square GMP Model is also called as single and double rotary tablet press machine and is commonly uses for slugging big tablets. We specialize in designing 8 station rotary tableting machine, 10 station rotary tableting machine, 12 station rotary tableting machine, 16 station rotary tableting machine, 27 station rotary tableting machine and 35 station rotary tableting machines according to the requirement of pharmaceutical and chemical industries.

* Power voltage can be adjusted as per customer’s domestic power voltage requirements.
* Rights of technical improvements & modification reserved.
* Illustrations & dimensions are shown for information purpose only.