Ampoule Filling and Sealing Machine

Ampoule Filling and Sealing Machine

Ampoule Filling and Sealing Machine or ampoule filler machine perform filling sealing built on advanced technology to fulfil the requirement in Pharmaceutical Filling Industry. Ampoules are filed with liquid then purged with nitrogen gas and finally sealed using combustible gases. Machine is having specially designed filling pump for precise filling of liquid with neck centering during filling operation. Ampoule are sealed immediately after filling the liquid in order to avoid contamination. Machine made from high quality stainless steel 316L materials as per cGMP requirements.

Machine having flexibility to fill seal ampoules of 1ml to 25ml capacity. Apart from that, machine has a unique filling capacity of 0.5ml to 25ml in single dosing. Operating on the volumetric piston-pumps type filling principle, the device can fill 10 to 250 ampoules per minute. Another unique advantage of this equipment is the availability of the dead-tray. It offers perfect diversion of the sealed and filled ampoules.

The required gases for sealing or filling the ampoules are oxygen and LPG (propane). This state-of-art machine provides optimum flexibility in the preparation of ampoules containing agro-insecticides, veterinary medicines, cosmetic ampoules and several other chemicals. This Adinath range of Filler Sealer is perfect for all kinds of open-mouth glass ampoules.

Ampoule Filling Machine Video

Types of Ampoule Filling Machines

We offer below mentioned different types of ampoule filling machines:

Exclusive Features of Ampoule Filling Machine

  • Compact cGMP model.
  • Suitable for filling 1ml to 30ml glass ampoules.
  • Filling and sealing in one unit – Monobloc type design.
  • Having application in pharmaceutical, biotech & biochemical.
  • Filling and sealing in one unit – Monobloc type design.
  • Contact parts made from heavy grade Stainless Steel 316L materials.
  • One motor synchronizes with all drives of the unit.
  • Facility of injecting Nitrogen before and after liquid filling.
  • 0.5ml to 25ml filling in single dosing.
  • Designed to fill and seal type B as well as type C open mouth ampoules.
  • Dead tray provided for upright placement of ampoules during collection.
  • Pre warming unit before sealing for perfect sealing of glass.
  • Change of format parts by hand without using any tool.
  • Delicate ampoule rotating unit attached at the ampoule opening and sealing station.
  • Waste tips collector made with the high-quality stainless steel.
  • IQ/OQ documentation can be provided.
  • PLC system with Graphical User Interface can be offered.
  • Inbuilt Laminar Air Flow can be offered for sterile class 100 filling.

Working Principle
of Ampoule Filling Machine

Empty ampoules are placed onto hopper of the machine from where it has been dropped to travelling rack in one/two/four/eight by format part. Ampoules advanced to nitrogen purging stations where inert gas needles flush nitrogen. Further ampoules moves to filling unit where filling needles discharge preset volume of liquid into ampoules. Then ampoules stop at post nitrogen unit where again nitrogen get flush inside the ampule. After filling of ampoules it reaches to the sealing unit which is having pre warming and sealing stations. Pre warming station is having less pressure flame which make ampoule warm up to sealing process. Specially designed rollers rotates ampoules at sealing unit for perfect sealing of ampoules all around. Sealing unit perform sealing operation of ampoules. At last ampoules get collected onto collection tray of the machine in upright position for further processing.

The machine performs the following operations:

  • Ampoule loading by hopper, star wheel transfers ampoule into transport rack.
  • One/Two/Four/Six/Eight ampoules advanced each machine stroke.
  • Centering of ampoules necks during warming, sealing, gas flushing and liquid filling operations.
  • Rotation of ampoules neck during warming and heating station.
  • Elimination of waste ampoule tips by clippers and ejection into a separate container.

Technical Specification
of Ampoule Filling Machine

Model AFS-1 AFS-2 AFS-4 AFS-8
No. of Head Single Two Four Eight
Syringes One Double Four Eight
Ampoule Sizes 1 ml to 30 ml 1 ml to 30 ml 1 ml to 10 ml 1 ml to 20 ml
Filling Speed Up to 25 ampoules/minute Up to 50 ampoules/minute Up to 100 ampoules/minute Up to 200 ampoules/minute
Filling Precision ± 1% ± 1% ± 1% ± 1%
Filling Pump Piston Pump Piston Pump Piston Pump Piston Pump
Burner Gas LPG & Oxygen (O₂) LPG & Oxygen (O₂) LPG & Oxygen (O₂) LPG & Oxygen (O₂)
Nitrogen Arrangement Before & After Filling Before & After Filling Before & After Filling Before & After Filling
Number of Fill Nozzles One Two Four Eight
Number of Nitrogen Nozzles Two Four Eight Sixteen
Number of Sealing Burners Two Four Eight Sixteen
Power Required 0.5 H.P. 1 H.P. 1 H.P. 2 H.P.
Power Voltage 230 Volts, Single Phase, 50 Hertz, 4 Wire System 230 Volts, Single Phase, 50 Hertz, 4 Wire System 230 Volts, Single Phase, 50 Hertz, 4 Wire System 230 Volts, Single Phase, 50 Hertz, 4 Wire System
Contact Parts Made from Stainless Steel 316L Made from Stainless Steel 316L Made from Stainless Steel 316L Made from Stainless Steel 316L
Overall Dimension 915mm (L) x 610mm (W) x 965mm (H) approx. 915mm (L) x 760mm (W) x 965mm (H) approx. 1200mm (L) x 1070mm (W) x 965mm (H) approx. 2200mm (L) x 1400mm (W) x 1100mm (H) approx.

* Power voltage can be adjusted as per customer’s domestic power voltage requirements.
* Rights of technical improvements & modification reserved.
* Illustrations & dimensions are shown for information purpose only.

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Ampoule Filling Machine of One, Two head, Four Head, Six Head and Eight head. Ampoule Filler Machine uses in Injectables which are Two Head Ampoule Filling Machine, Four Head Ampoule Filling Machine, Six Head Ampoule Filling Machine, Eight Head Ampoule Filling Machine and Lab Scale Ampoule Filling Machines. Option of Safety Cabinet/Laminar Air Flow/ISOLATOR available as per individual requirements. Our ampoule filling machine can be categorized in below sections

  • Ampoule Filling Machine
  • Automatic Ampoule Filler
  • Automatic Ampoule Filling Machine
  • Single Head Ampoule Filling Machine
  • Four Head Ampoule Filling Machine
  • Two Head Ampoule Filling Machine
  • High Speed Ampoule Filling Machine
  • Eight Head Ampoule Filling Machine
  • Onion Skin Ampoule Filling Machine
  • Cosmetic Ampoule Filling Machine
  • Glass Ampoule Filling Machine
  • Ampoule Filling And Sealing Machine
  • Ampoule Filling & Sealing Machine

Many our different models of Ampoule Filling Machine suitable as per need of small, medium & large volume sterile injectable preparations.

Single Head Ampoule Filling & Sealing Machine having output of 1500 ampoules/hour suitable for lab scale production.

Four Head Ampoule Filling & Sealing Machine having output of 6000 ampoules/hour suitable for medium scale production.

High Speed Ampoule Filling Machine having output of 12000 ampoules/hour suitable for large scale production.

We provide integrated Ampoule Filling Line which is having Ampoule Washing, Sterilization Tunnel, High Speed Ampoule Filling Machine and Ampoule Sticker Labeling Machine. These production lines available in capacity of 200 ampoules/minute and 300 ampoules/minute production range.

Our Ampoule Filling Machine suitable for filling 1ml, 2ml, 3ml, 5ml, 10ml, 20ml, 25ml and 30ml ampoule sizes. We manufacture injectable plant machineries which includes Ampoule Vial Washing Machine, Ampoule Filling and Sealing Machine, Ampoule Filler Machine, Ampoule Inspection Machine, Ampoule  Sticker Labeling Machine.  Apart from it we manufacture Vial Liquid Filling Machine, Vial Powder Filling Machine, Injectable Powder Filling Machine, Vial Cap Sealing Machine, Vial Labelling Machine and Dry Syrup Powder Filling Machines.

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