Monoblock Syringe Filling & Stoppering Machine or pre filled syringe filling machine is suitable for performance demanding customers in pharmaceutical, biotech & veterinary industry. Machine is compact in design work on PLC based automatic control panel and complies as per cGMP requirements. All contact parts are made from Stainless Steel 316L or FDA approved materials for cGMP compliance.
Machine is compact, elegant and matt – finished encompassed with Stainless Steel 304. Perfect synchronization of PLC based cycle, filling stroke and syringes to fill different volume. Compact and feather-touch MMI control panel for easy control of the machine operation The machine is equipped with easily adjustable leveling legs so foundation is not required. Nitrogen Filter is provided Pre-Filter 0.5 micron and Final Filter of 0.2 micron. Machine is having Air Filter of 0.2 micron.
Exclusive Features of Pre Filled Syringe Filling Machine
- Compact GMP Model.
- Higher filling accuracy of ±1% in single dosing.
- PLC operated elegant and easy control panel for total control on operation.
- Rigid vibration free construction for trouble free performance.
- Stainless Steel elegantly matt finished body.
- Minimum change overtime, from one size to another Syringe or fill size.
- All the contact parts made from Stainless Steel 316 material.
- Machine is a Compact, elegant and matt finished made with SS 304.
- Stainless Steel 316 Vacuum Chamber.
- Pneumatic controlled Stoppering head.
- Elegant and easy control panel for total control on operation.
- Minimum change overtime, from one size to another container.
- IQ/OQ documentation can be provided.
- PLC system with Graphical User Interface can be offered.
- Inbuilt Laminar Air Flow can be offered for sterile class 100 filling.
- Sampling and Rejection system can be provided on demand.
Working Principle of Pre Filled Syringe Filler Equipment
- Syringes has to be load onto a tray of 100 pre filled syringes (depends upon syringe size) onto Stainless Steel Stand. After loading procedure, tray has to be put onto filling station of the machine.
- Operator has to start filling operation from control panel of the machine.
- Automatic filling cycle starts in 10 steps with at a time 10 syringes will be filled with help of Stainless Steel Valve less Syringes.
- After Filling Operations, one has to taken back tray of filled syringes and have to load onto the stoppering unit. Stoppering Unit is having similar type of tray loading mechanism as of Filling Unit.
- After loading one has to close the evacuation & Stoppering chamber.
- Now, start the stoppering operation from the control panel of the machine.
- Automatic stoppering cycle starts one by one as per the programmed Stoppering cycle mentioned as under. 100 Stoppers are plugged into the Pre-filled syringes precisely after vacuum hold cycle. (Stoppering & Evacuation cycle details is mentioned in below of this page)
- Now last cycle of nitrogen flushing with vacuum break completes the Stoppering operation.
- Now syringes are filled and stoppered. One can unload Tray from the machine for transfer it in desired area.
Technical Specification of Pre Filled Syringe Filler
|
Model |
PFSM – 40 |
|
No. of Filling Syringes |
Two |
|
Tray Holes |
10 rows x 10 nos. = 100 holes |
|
Filling Volume |
0.5ml to 5ml |
|
Production Output |
Up to 1440 syringes/hour |
|
Filling Accuracy |
± 1% |
|
Utility |
Purified Air and Nitrogen |
|
Electrical Characteristics |
230 Volts, Single Phase, 50 Hertz, 4 Wire System |
|
Contact Parts |
Made from Stainless Steel 316L |
|
Non-Contact Parts |
Made from Stainless Steel 304 |
|
Overall Dimension |
1300mm (L) x 600mm (W) x 1200mm (H) approx. |
|
Net Weight |
250 kgs. approx. |
|
Gross Weight |
375 kgs. approx. |
|
Change Parts – Filling Unit |
Filling Syringes for 5ml – 10ml (If required) |
| Change Parts – Stoppering Unit |
|
* Power voltage can be adjusted as per customer’s domestic power voltage requirements.
* Rights of technical improvements & modification reserved.
* Illustrations & dimensions are shown for information purpose only.
FAQ of Pre Filled Syringe Filling Machine
How does the Pre Filled Syringe Filling Machine work?
Syringes are loaded in trays (typically 100 syringes) onto the filling station. The machine performs an automatic filling cycle in steps, filling 10 syringes at a time using stainless steel valveless syringes with ±1% accuracy. Filled syringes are then transferred to the stoppering unit, where vacuum evacuation, stoppering, and nitrogen flushing occur in a controlled chamber. The process ensures precise filling, bubble-free stoppering, and product integrity.
What are the key features of this machine?
- Compact GMP model with SS 304 matt finish body and SS 316L contact parts.
- High filling accuracy of ±1%.
- PLC-based control panel with easy MMI operation.
- Vacuum stoppering with pneumatic control and nitrogen flushing.
- Minimum changeover time between syringe sizes.
- Options for inbuilt Laminar Air Flow (Class 100), IQ/OQ documentation, and sampling/rejection systems.
- Rigid, vibration-free construction for reliable performance.
What is the production capacity and filling range?
The standard model (PFSM-40) can produce up to 1,440 syringes per hour. It supports a filling volume range of 0.5 ml to 5 ml. It uses a tray system with 100 holes (10x10) and two filling syringes for efficient operation.
Why choose Adinath’s Pre Filled Syringe Filling Machine?
It offers excellent filling accuracy, full cGMP compliance, and advanced features like vacuum stoppering and nitrogen flushing to maintain product sterility and stability. The machine requires no foundation (adjustable leveling legs), has quick changeover, and can be customized with options like Graphical User Interface and Laminar Air Flow, making it suitable for high-demand sterile filling applications.