All About Tablet Granulation Line
One or more powder particles are mixed during the granulation process to create granules that will enable tableting to occur within the necessary parameters. It is the act of uniting separate particles by forging ties between them, and these bonds are made possible by the use of a binding agent. The pharmaceutical industry uses this granulation procedure frequently to create tablets and pellets. Various pharmaceutical machinery are needed for the tablet granulation line process, and those machines are listed below.
Fluid Bed Processor, Fluid Bed Dryer
The two-piece stainless steel Fluid bed processor, also known as a fluidized bed dryer, is used to dry fluidized beds. These fluid bed dryers are employed in the mixing and agglomeration of dry powders. To lower the moisture content of granules and powder, this fluid bed drier is widely used in the pharmaceutical industry.
The fluid drying machine’s superior gas-particle constant allows it to remove moisture from powders and granules at a rapid rate, resulting in high mass and high heat transfer rates. These fluid bed processors need a minimum amount of physical labor, have streamlined maintenance, and offer flexible installation options.
Rapid Mixer Granulator/Tablet Granulation Line
The Rapid Mixer Granulator (RMG) is a piece of machinery that is frequently employed in the pharmaceutical sector. These granulators are also used to create granules for the compression process, and these mixers are utilized to combine two separate medicinal substances to create one. These quick mixers have many components that are employed in the mixing process, including
- Impellers: These impellers, which have two full-length and two half-length blades, are at the bottom of the apparatus. The material is lifted using half-length blades, and the particles are mixed using full-length blades.
- Choppers: Choppers are the tiny blades that are located at the machine’s dome and are used to chop up damp lumps and provide uniform granulation.
- Discharge Port: A compressed air-operated cylinder, sometimes known as a pneumatic cylinder, controls this discharge port. These discharge ports are responsible for loading the grains into the container.
All of the aforementioned quick mixer granulator’s component parts.
Multi Mill
In the pharmaceutical industry, a Multi Mill is used for both wet and dry granulation and pulverization. This multi-milling machine operates on the basis of swing beaters with variable forces, each of which has a revolving knife and impact edge within a perfect screen to achieve the desired size reduction. This portable mill device is helpful for efficiently blending a variety of wet and dry materials as well as high-speed granulation pulverizing.
These mills are simple to disassemble and clean on the inside and outside. It is one of the most preferred machines used in the granulation line process due to its dependability, minimal maintenance costs, and high degree of performance.
V- Blender
A dependable and adaptable tool for blending identical dry powders, the “V” blender is used for mixing and lubricating. To ensure that proper mixing is taking place, the Blender is filled to about two-thirds of its capacity. Diffusion is a V-main Blender’s blending property.
This diffusion blending typically takes place when the particles are dispersed across a recently developed interface. The apex port on these V-blenders, which is equipped with a discharge valve, is typically used to carry out the discharge procedure.
Due to its ideal medium speed and “V”-shaped vessel, this “V” Blender produces the greatest results for powders. All of the equipment listed above are different pharmaceutical machines used in the tablet granulation process, with a thorough context detailing the operation and features of each machine.