BENIFITS OF A WET GRANULATION LINE
An extremely effective piece of machinery used in the manufacture of pharmaceutical products is a wet granulation line. Reduced dust pollution, homogeneous drug ingredient in the final dose form, and simplicity of regulation are some of its advantages. This equipment also includes food-grade chrome-plated steel components and a dust collection bag. Additionally, the internal temperature can be adjusted simply.
WET GRANULATION LINE REDUCES DUST POLLUTION
During industrial processes, wet granulation can lessen the amount of dust generated. It lessens air entrapment, lessens batch size variability, and improves powder compressibility. While not all powders are appropriate for wet granulation, some can benefit from it.
Wet granulation methods have been greatly improved by in-line assessment of bulk powder qualities. Real-time information can be provided by this technology to monitor important processes and increase process effectiveness. Additionally, it raises the standard of the finished item. Monitoring tableting blends, granules, or tablets is possible with the use of this technology.
An essential factor that affects granulate activity is grain particle size. The factors that affect grain particle size were investigated, and methods for controlling them were developed. Temperature and the internal diameter of the nozzle used to feed the melt were the two most crucial technological factors.
The quality of the main granule is also significantly influenced by its size. A sizable portion of the powder may be amorphous, whereas a minor portion may be glassy. The degree of grain size, the level of external porosity, and the level of structure all affect how much glassy phase is present in granules.
WET GRANULATION LINE IMPROVES UNIFORMITY OF DRUG SUBSTANCE IN FINAL DOSAGE FORM
Manufacturers must carefully choose the best production techniques in order to increase the consistency of drug material content in final dosage forms. Wet granulation or dry granulation based on roller compaction are both acceptable methods. Both of these procedures include an additional mixing step that modifies the medication and excipient particle sizes. To guarantee uniform distribution, the choice of medication loading technique is crucial.
Making sure the medication component is evenly dispersed throughout the powder blend is one of the main problems in producing a low-dose solid dosage form. When the drug ingredient flows poorly or has a large variety of particle sizes, this method can be difficult. The drug ingredient must be co-micronized with excipients that have similar particle sizes in order to ensure uniform distribution. In order to facilitate BU, the process may involve sieving via a tiny aperture.
WET GRANULATION LINE REDUCES DUST DURING MANUFACTURING PROCESS
The purpose of the pharmaceutical wet granulation process is to optimize the feed for subsequent processing by changing the qualities of a powder blend. The procedure is perfect for various pharmaceutical applications since it is adaptable, effective, and reproducible. It produces homogenous, dense granules that are prepared for tableting thanks to its quick processing time and perfect dispersion. It is a necessary step in the production of several oral solid dosage forms.
Granulation, blending, and drying are some of the processes that make up this process. This frequently leads to a lot of manual labor and a potentially dangerous atmosphere. Integrated granulation systems streamline the procedure and increase worker safety. Operating in a closed-loop system protects workers from exposure to hazardous dust and vapor. Closed-loop procedures are also more effective and dependable.
The addition of lubricant to the powder mixture is the first stage in wet granulation. The lubricant facilitates easier granule flow. Lubricant content can range from 0.1% to 5% of the final product weight, depending on the formulation scientist. It could take the shape of stearic acid, calcium stearate, or magnesium stearate.
IMPROVES PRODUCT QUALITY WITH WET GRANULATION LINE
High shear wet granulation (HSWG) is a multifaceted procedure with numerous factors that influence the final product’s quality. Understanding and regulating these factors is essential for the most effective product development. In this post, we’ll look at the fundamental ideas and recommended methods for HSWG-based product development and show you how to put these ideas into reality.
Wet granulation operations can be effectively managed by measuring wet mass concentration, flow resistance, and particle contact with a DFF sensor. This technique can be applied to formulating, developing processes, and routine monitoring. DIA can offer details on particle size and shape in addition to accuracy.
The integrated granulation train is another important advantage of a wet granulation line. It is essential for procedures using organic solvents or moisture-sensitive items that dust and vapor are contained while moving products from one location to another. The closed-container design also eliminates the possibility of product tampering. This promotes the security of the operating staff.
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