The Closed Ampoule Filling Machine fills and seals closed-mouth glass ampoules while focusing on maintaining sterility and precision in the pharmaceutical industry, making it a reliable choice with international standards. This GMP-compliant monoblock design combines ampoule opening, filling, and sealing operations in a single platform.
Closed Ampoule Filling Machine Video
Sterile Construction for Critical Environments
Fabricated from SS 316L contact parts, the entire machine is made of stainless steel construction and built in accordance with GMP and FDA standards. The seamless design provides a reduced contamination risk and is compatible with cleanroom integration and easy sterilization, allowing compliance with aseptic manufacturing protocols.
How It Works?
Infeed Hopper
The infeed hopper is loaded with sterilized closed-mouth ampoules.
Star Wheel
A star wheel or cassette puts them onto a moving rack, which carries the ampoules at an angle past different stations:
Pre Gassing
In a pre-gassing step, nitrogen gas is flushed into the ampoule to exchange oxygen.
Filling
The filling liquid product is accurately filled into aseptically closed ampoules.
Flushing
Additional nitrogen flushing is done after gassing to safeguard the product.
Sealing
The ampoule is hermetically sealed with a flame to keep the product free from contamination.
Collection Tray
The filled and sealed ampoules are automatically collected on the collection tray.
Key Features of Ampoule Filling Machine
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GMP Compact Format: Current Good Manufacturing Practice focused on quality and safety of products.
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Material: Built using SS316L for contact parts and SS304 for noncontact parts.
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Throughput: Up to 12,000 ampoules per hour, depending on model.
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Wide Range of Ampoule Sizes: Can handle ampoules from ~1ml to 10ml, some models can go up to 30ml.
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No Ampule–No Fill: Eliminates wastage by allowing fill to happen only when the ampule is present.
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Ampoule Neck Centering: Allows precise flushing and filling of the gas.
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Nitrogen Flushing: Options that let nitrogen gas be injected before, during, and after filling to help protect the product.
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Pre-Warming Station: This add-on is used to pre-warm ampoules before the actual sealing process to create a secure seal.
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Flame Adjustment: The Use of flow meters adjusts sealing flames easier.
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Short Change Over Time: This is specially developed for fast conversion to accommodate various ampoule sizes.
Technical Highlights
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Filling Precision: ±1%
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Filling Mechanism: Piston pump-based volumetric filling
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Sealing System: Flame sealing using LPG & Oxygen (O₂)
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Ampoule Type: Closed-mouth glass ampoules
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Nitrogen Flushing: Available (pre, during & post-filling)
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Construction: GMP-compliant stainless steel build
Technical Specification of Ampoule Filling Machine
| Model | AFS-1C | AFS-2C | AFS-4C | AFS-8C |
| Filling Heads | Single | Two | Four | Eight |
| Ampoule Size Range | 1ml to 30ml | 1ml to 30ml | 1ml to 20ml | 1ml to 20ml |
| Filling Speed | Up to 25 ampoules per minute | Up to 50 ampoules per minute | Up to 100 ampoules per minute | Up to 200 ampoules per minute |
* Power voltage can be adjusted as per customer’s domestic power voltage requirements.
* Rights of technical improvements & modification reserved.
* Illustrations & dimensions are shown for information purpose only.
*Specifications are subject to change according to certain technical advancements and customer needs.
The Closed Ampoule Filling and Sealing Machine manufactured by Adinath demonstrates the company’s dedication to providing pharmaceutical machinery that is high quality, reliable, easy to use, and meets all industry standards and requirements.
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